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  • Title: Stimulating effect of alpha-adrenoceptor agonists on isoproterenol-induced amylase release in rat parotid tissue.
    Author: Ohshika H, Takemura H, Endo J, Hatta S, Tanaka M.
    Journal: Jpn J Pharmacol; 1981 Dec; 31(6):1021-7. PubMed ID: 6174762.
    Abstract:
    Isoproterenol (ISO)-induced amylase release from rat parotid slices was increased by the addition of methoxamine to either a normal or a calcium (Ca)-free medium. The potentiating effect of methoxamine was completely blocked by the addition of phentolamine, irrespective of whether the slices were incubated in the normal or the Ca-free medium; and the effect also disappeared after prolonged preincubation (60 min) of the slices in the Ca-free medium. Both verapamil and procaine reduced methoxamine-induced amylase release, but only verapamil blocked the stimulating effect of methoxamine in the normal medium. ISO-induced accumulation of cyclic AMP in the slices was unaffected by methoxamine or phenylephrine. The results suggest a possibility that the potentiating effect of methoxamine on ISO-induced amylase release may be independent of the presence of extracellular Ca and the increased accumulation of cyclic AMP in the tissue is unnecessary.
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