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  • Title: Genetic damage caused by methylazoxymethanol acetate, the aglycone of cycasin. Analysis of sister-chromatid exchange frequency under in vivo conditions and in cell cultures.
    Author: Gloser H.
    Journal: Oncology; 1982; 39(2):101-3. PubMed ID: 6174910.
    Abstract:
    To extend the information on the mutagenic effect of methylazoxymethanol (MAM) acetate, which has been established as a potent carcinogen, the frequency of sister-chromatid exchange (SCE) was determined in bone marrow cells of Sprague Dawley rats and in cultured rat lymphocytes. To get differentially stained chromatids under in vivo conditions, the rats received 5-bromodeoxyuridine adsorbed on activated charcoal intraperitoneally. Chromosomes were stained with fluorescence plus Giemsa. In this study a significant increase of SCE frequency after the application of various concentrations of MAM acetate could be observed both in vivo and in vivo.
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