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  • Title: Studies on the plasma membrane of normal and psoriatic keratinocytes. 5. Lectin binding.
    Author: Gommans JM, van den Hurk JJ, Bergers M, van Erp P, Mier PD, Roelfzema H.
    Journal: Br J Dermatol; 1982 Mar; 106(3):317-22. PubMed ID: 6175329.
    Abstract:
    The glycocalyx of epidermal keratinocytes from psoriatic patients has been investigated by means of lectins. Striking changes were found in the levels of glucose and/or mannose (concanavalin A) and of N-acetylglucosamine and/or sialic acid (wheat germ agglutinin) on the surface of cells from the psoriatic lesion. Smaller but significant changes were seen in the clinically uninvolved epidermis of the patient. A marked increase in the affinity of the cell surface for Ulex europus agglutinin (fucose-specific) confirms our previous reports of structural alterations in fucose-containing oligosaccharides in psoriasis.
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