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  • Title: Combined immunological and histochemical analysis of skin and lymph node lesions in histiocytosis X.
    Author: Thomas JA, Janossy G, Chilosi M, Pritchard J, Pincott JR.
    Journal: J Clin Pathol; 1982 Mar; 35(3):327-37. PubMed ID: 6175664.
    Abstract:
    The immunological phenotype of the cells involved in skin and lymph node lesions from two cases of histiocytosis X (H-X) were analysed by immunofluorescence techniques using combinations of heterologous and monoclonal antisera to Ia-like antigen and human cortical thymocyte (HTA-1) determinant. These cells were also characterised by a new technique using simultaneous immunofluorescence and enzyme histochemistry for acid phosphatase (ACPase). The major cell type in the lesions was found to express the same Ia+, HTA-1+ phenotype as normal epidermal Langerhans' cells (LC) and was unreactive for ACPase. Additional cell types included Ia-, HTA-1- multinucleate giant cells and residual lymphoid populations. These findings endorse previous concepts that H-X is a proliferation of abnormal LC and emphasise the heterogeneous nature of the cells involved in the disease.
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