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  • Title: The dual-system hypothesis of pain perception.
    Author: Gillman MA, Kimmel I, Lichtigfeld FJ.
    Journal: Neurol Res; 1981; 3(4):317-27. PubMed ID: 6175917.
    Abstract:
    We describe a dual-system hypothesis relating the seemingly contradictory findings reported in clinical and experimental investigations of pain. This incorporates a model in which two neuronal systems are related, involving Substance P (SP) and Enkephalin (E). This model uses feedback loops holding the systems in balance. The analogy to a control system is also made.
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