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  • Title: Association of globin ribonucleic acid and its precursors with the chicken erythroblast nuclear matrix.
    Author: Ross DA, Yen RW, Chae CB.
    Journal: Biochemistry; 1982 Feb 16; 21(4):764-71. PubMed ID: 6176264.
    Abstract:
    Nuclear matrix was prepared from both erythroblasts and erythrocytes of chicken red blood cells. Greater than 90% of the globin nuclear RNA remains bound to the erythroblast nuclear matrix. There are approximately 1000 copies of globin RNA in the nucleus per cell, and most of these contain a poly(A) tail. Precursor beta globin RNA exists in four high molecular weight forms, some of which are larger than the natural beta globin gene. Most of the ribosomal RNA is lost during the preparation of an erythroblast nuclear matrix. In contrast, some of the snRNAs are specifically enriched in the erythroblast nuclear matrix. There is little or no globin nuclear RNA in the erythrocyte nuclear matrix. There appears to be no selective attachment of the globin genes to the erythroblast nuclear matrix. The nuclear matrix is postulated to be a platform for the differential processing of nuclear RNA.
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