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  • Title: Effect of ketotifen and oxatomide on histamine secretion from mast cells.
    Author: Truneh A, White JR, Pearce FL.
    Journal: Agents Actions; 1982 Apr; 12(1-2):206-9. PubMed ID: 6177216.
    Abstract:
    The anti-histaminic drugs ketotifen and oxatomide have a dual effect on rat peritoneal mast cells. At high concentrations they induce histamine release, whereas at low concentrations they inhibit secretion evoked by IgE-directed ligands. The latter effect is observed in the presence and absence of exogenous calcium. The significance of this result for the general mode of action of anti-anaphylactic drugs is discussed. Neither compound liberates histamine from isolated mesenteric cells from the rat or guinea pig, further emphasizing the functional heterogeneity of mast cells from different sources.
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