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  • Title: Development and application of a radioimmunoassay for pepleomycin.
    Author: Aherne GW, Saesow N, James S, Marks V.
    Journal: Cancer Treat Rep; 1982 Jun; 66(6):1365-70. PubMed ID: 6177409.
    Abstract:
    A rapid sensitive radioimmunoassay for pepleomycin (PM) has been developed using an antiserum produced in a sheep in response to a bovine serum albumin-drug conjugate. Radioiodinated PM was prepared using Iodogen. The assay was reproducible with a limit of detection in plasma of 200 ng/liter. The antiserum does not cross-react with bleomycin or with a number of unrelated drugs. Pharmacokinetic studies using the assay were carried out in three patients who received a short iv infusion of 5 mg/m2 of PM. The drug disappeared from the plasma with an elimination half-life of approximately 3 hours.
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