These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration.
    Author: Friedman HS, Chen TS.
    Journal: Am Heart J; 1982 Jul; 104(1):72-6. PubMed ID: 6178280.
    Abstract:
    Serum digoxin and/quinidine concentration were measured before and following the institution of quinidine therapy in 11 patients who were receiving maintenance oral digoxin therapy and who required quinidine therapy for suppression of extrasystoles. Steady-state serum digoxin concentrations after quinidine administration were found to correlate well with serum digoxin concentrations before quinidine therapy and with peak serum digoxin concentrations after the first dose of quinidine sulfate, but not with serum quinidine concentrations. Thus steady-state serum digoxin concentration after quinidine (Y) could be estimated from the steady-state serum digoxin concentration before quinidine (X) as expressed by the regression formula Y = 2.6X - 0.6, with Syx2 - 0.21, and r = 0.96 (p less than 0.01). Based on these observations, guidelines for administering digoxin with concomitant quinidine therapy are presented.
    [Abstract] [Full Text] [Related] [New Search]