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  • Title: [Gramicidin A-induced membrane conductance of isolated muscle fiber].
    Author: Shvinka NE, Caffier G, Malev VV.
    Journal: Biofizika; 1982; 27(3):445-9. PubMed ID: 6178439.
    Abstract:
    The conductance of single fibres from m. ileofibularis of Rana esculenta was studied in isotonic K2SO4 solution under constant--current conditions using the double sucrose gap method. The antibiotic gramicidin A effects a drastic increase of membrane conductance. Variation of the gramicidin-induced conductance with gramicidin concentration in the bathing solution (10(-8)-5,5 . 10(-7) M) was investigated. Gramicidin-induced conductance was proportional to the square of gramicidin concentration in the solution, as expected in a channel made of gramicidin dimer.
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