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  • Title: Interferon action in human fibroblasts: induction of 2', 5'-oligoadenylate synthetase in the absence of detectable protein kinase activity.
    Author: Holmes SL, Gupta SL.
    Journal: Arch Virol; 1982; 72(1-2):137-42. PubMed ID: 6179503.
    Abstract:
    In several strains of human fibroblasts, treatment with human alpha- or beta-interferon (IFN) resulted in an induction of 2', 5'-oligoadenylate synthetase but no protein kinase activity. The antiviral and anticellular effects of IFN are elicited in these cells in the absence of detectable IFN-induced protein kinase activity.
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