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  • Title: Palliative treatment of tardive dyskinesia with combination of amantadine-neuroleptic administration.
    Author: Allen RM.
    Journal: Biol Psychiatry; 1982 Jun; 17(6):719-27. PubMed ID: 6179548.
    Abstract:
    The author presents six cases which suggest a palliative effect of combination amantadine/neuroleptic in tardive dyskinesia. The six patients all met criteria for definite tardive dyskinesia, and did not have coexistent pseudoparkinsonism. Serial addition and subtraction of amantadine with fixed low-dose neuroleptic points to a specific amantadine effect. Previous studies are reviewed and speculation about the mechanism of action of the combination is discussed.
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