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  • Title: Effect of gamma interferon preparations on in vitro phagocytosis and degradation of Escherichia coli by mouse peritoneal macrophages.
    Author: Degré M, Sonnenfeld G, Rollag H, Mørland B.
    Journal: J Interferon Res; 1981; 1(4):505-12. PubMed ID: 6180084.
    Abstract:
    Treatment of mouse peritoneal macrophages by gamma (type II, immune) interferon depressed the ingestion of non-opsonized Escherichia coli mediated by the non specific receptor, and also the intracellular degradation of the ingested bacteria. These effects were time and dose-dependent, and sensitive for trypsin and pH 2 treatment. The intracellular concentration of three lysozomal enzymes, beta-glucuronidase, acid phosphatase and cathepsin D, was elevated in gamma interferon-treated macrophages.
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