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  • Title: The role of liver in the catabolism of human alpha- and beta-interferon.
    Author: Bocci V, Pacini A, Bandinelli L, Pessina GP, Muscettola M, Paulesu L.
    Journal: J Gen Virol; 1982 Jun; 60(Pt 2):397-400. PubMed ID: 6180128.
    Abstract:
    The susceptibility of human leukocyte (alpha), fibroblast (beta) and recombinant alpha-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant alpha-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that alpha-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human beta-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.
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