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  • Title: The mode of action of berninamycin and mechanism of resistance in the producing organism, Streptomyces bernensis.
    Author: Thompson J, Cundliffe E, Stark MJ.
    Journal: J Gen Microbiol; 1982 Apr; 128(4):875-84. PubMed ID: 6181185.
    Abstract:
    The mode of action of berninamycin on bacterial protein synthesis is related to that of thiostrepton, a dissimilar compound. Both antibiotics bind to the complex of 23S RNA with protein L11 and both affect various functions of the ribosomal A site. Also, Streptomyces bernensis and Streptomyces azureus (which, respectively, produce berninamycin and thiostrepton) possess similar ribosomal RNA methylases capable of rendering ribosomes resistant to these compounds. Resistance involves specific pentose-methylation of 23S ribosomal RNA.
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