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  • Title: Demonstration that the temporary sequestering of adventitious iron accounts for the inhibition of microsomal lipid peroxidation by bleomycin A2.
    Author: Trush MA.
    Journal: Res Commun Chem Pathol Pharmacol; 1982 Jul; 37(1):21-31. PubMed ID: 6181545.
    Abstract:
    One of the manifestations of the interaction of bleomycin with the microsomal mixed-function oxidase system is an inhibition of NADPH-dependent, reactive oxygen-mediated lipid peroxidation. The results of this investigation demonstrate that this effect by bleomycin can be attributed to the sequestering of adventitious iron. However, as a result of the microsome-catalyzed, iron-facilitated activation of bleomycin and the concomitant spontaneous decay of the activated bleomycin intermediate, iron can apparently no longer be bound by the bleomycin molecule; consequently, the inhibition of microsomal lipid peroxidation by bleomycin is only temporary.
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