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  • Title: Reduction of plasma levels of betathromboglobulin and platelet factor 4 during hemodialysis: a possible role for a short acting inhibitor of platelet aggregation.
    Author: Buccianti G, Pogliani E, Miradoli R, Colombi MA, Valenti G, Lorenz M, Polli EE.
    Journal: Clin Nephrol; 1982 Oct; 18(4):204-8. PubMed ID: 6183040.
    Abstract:
    Plasma levels of the platelet markers betathromboglobulin and platelet factor 4 are elevated in patients with chronic renal failure, and their levels in hemodialysis patients increase further during exposure to the dialysis membrane. The effectiveness of a short acting inhibitor of platelet aggregation in reducing the blood levels of betathromboglobulin and platelet factor 4 was assessed by means of a double blind cross over study. A statistically significant reduction of betathromboglobulin and platelet factor 4 levels was observed during treatment with the platelet inhibitor.
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