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  • Title: Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides.
    Author: Sanchez Y, Ionescu-Matiu II, Sparrow JT, Melnick JL, Dreesman GR.
    Journal: Intervirology; 1982; 18(4):209-13. PubMed ID: 6183231.
    Abstract:
    A cyclic peptide containing the amino acid sequence 122 through 137 of the major hepatitis B surface antigen (HBsAg) polypeptide was synthesized. The immunogenicity of this synthetic peptide, aggregated in micelles or covalently coupled to tetanus toxoid, was assessed in mice. Antibodies against HBsAg (anti-HBs) were obtained with both preparations, administered either in saline suspension or adsorbed on aluminum gel. The peptide-tetanus toxoid conjugate was more immunogenic than the peptide micelles, producing high levels of specific anti-HBs.
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