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Title: Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum. Author: Barthó L, Holzer P, Donnerer J, Lembeck F. Journal: Neurosci Lett; 1982 Sep 20; 32(1):69-74. PubMed ID: 6183624. Abstract: In the isolated, vascularly perfused guinea-pig ileum, peristalsis could be induced by raising the intraluminal pressure in the presence of atropine. Atropine-resistant peristalsis was greatly inhibited or abolished by the substance P antagonist (D-Pro2, D-Trp7.9)-substance P, substance P desensitization, hexamethonium and by the enkephalin analogue FK 33-824. It is concluded that substance P neurones of the intestine play an important role in the atropine-resistant peristalsis of the guinea-pig ileum.[Abstract] [Full Text] [Related] [New Search]