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  • Title: The release of histamine from rat mast cells by chymotrypsin.
    Author: Nials AT, Vardey CJ, Skidmore IF.
    Journal: Int Arch Allergy Appl Immunol; 1983; 70(1):83-7. PubMed ID: 6184324.
    Abstract:
    The release of histamine from rat peritoneal mast cells induced by alpha-chymotrypsin and that induced by antigen have characteristics in common. The kinetics of histamine release initiated by the two agents are similar. Both alpha-chymotrypsin and antigen release histamine in the absence of extracellular calcium, phosphatidyl serine enhances the release, and disodium cromoglycate inhibits both reactions. In contrast, extracellular alpha-chymotrypsin does not induce histamine release from cells isolated from fragments of human lung, human basophils, histamine-containing cells lavaged from the bronchial lumen of the rhesus monkey, fragments of human lung and fragments of guinea pig lung.
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