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  • Title: Neural-tube defect risk assessment for individual pregnancies using alphafetoprotein and acetylcholinesterase test results.
    Author: Strike PW, Smith J.
    Journal: J Clin Pathol; 1982 Dec; 35(12):1334-9. PubMed ID: 6184385.
    Abstract:
    Pregnancies at risk of being associated with (open) neural tube defects can be identified by maternal serum and amniotic-fluid alphafetoprotein (AFP) concentrations in excess of established screening cut-off valves in conjunction with the results of an amniotic fluid electrophoretic acetylcholinesterase screening test. The risk associated with the AFP cut-off values are formulated in terms of a population screening programme. These "population risks" are of little value in the assessment of test results from individual "at-risk" pregnancies, especially when the observed AFP concentrations are in proximity to the "cut-off" values. A complete risk assessment procedure for individual pregnancies is described and presented in graphical form to permit immediate access by clinical staff.
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