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  • Title: Lysine transfer RNA2 is the major target for L-ethionine in the rat.
    Author: Kuchino Y, Sharma OK, Borek E.
    Journal: Biochemistry; 1978 Jan 10; 17(1):144-7. PubMed ID: 618538.
    Abstract:
    Ethionine, a hepatocarcinogen, ethylates macromolecules in vivo especially tRNA of rat liver. When rats were injected with L-[ethyl-3H]ethionine, the tRNA fraction of the liver was found to be labeled. One tRNA with the highest specific activity was purified and identified as lysine-tRNA2.
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