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  • Title: Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response.
    Author: Rothstein TL, Margolies MN, Gefter ML, Marshak-Rothstein A.
    Journal: J Exp Med; 1983 Feb 01; 157(2):795-800. PubMed ID: 6185619.
    Abstract:
    Two hapten-inhibitable murine monoclonal antiidiotopic antibodies identified two idiotopes expressed by the heavy chain of hybridoma protein 36-65, whose amino acid sequence is encoded in the germ line of A/J mice. Among cross-reactive idiotype-positive hybridoma proteins and p-azophenylarsonate-immune antibodies, the two idiotopes were not always expressed together; some diversified antibodies expressed one idiotope without the other. Suppression that was induced by the two antiidiotopes was idiotope specific and corresponded to the fine specificities of these two reagents.
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