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  • Title: Indomethacin and aspirin do not inhibit the antiviral or anti-proliferative actions of interferon.
    Author: Tovey MG, Gresser I, Rochette-Egly C, Begon-Lours-Guymarho J, Bandu MT, Maury C.
    Journal: J Gen Virol; 1982 Dec; 63(2):505-8. PubMed ID: 6185629.
    Abstract:
    Neither indomethacin nor aspirin, at concentrations which inhibited the formation of prostaglandins and prevented the interferon-induced increase in the intracellular concentration of cyclic GMP, had any significant effect on the development of the interferon-induced antiviral state either in mouse L1210 cells challenged with vesicular stomatitis virus or in mice infected with encephalomyocarditis virus. Furthermore, neither drug had any significant effect on the interferon-induced inhibition of cell multiplication in cultures of mouse leukaemia L1210 cells. The differences in the effects of these cyclo-oxygenase inhibitors on different interferon effects may provide some insight into the different pathways of interferon action.
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