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  • Title: Chlordecone neurotoxicity: a brief overview.
    Author: Tilson HA, Mactutus CF.
    Journal: Neurotoxicology; 1982 Oct; 3(2):1-8. PubMed ID: 6186953.
    Abstract:
    Chlordecone or Kepone is a polycyclic chlorinated hydrocarbon insecticide that produces hyperexcitability, tremor, and other signs of nervous system toxicity. In addition, chlordecone has estrogenic-like effects and disturbs neuroendocrine function. Studies at the neurochemical level indicate that chlordecone inhibits neurotransmitter uptake; steady-state levels of biogenic amines are generally resistant to chlordecone, especially in mice. At the subcellular level, chlordecone may destabilize membrane function by altering energy metabolism and/or the disposition of ions required for neural transmission.
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