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  • Title: Leukotrienes and lipoxygenase factors: mediators and modulators of the allergic reaction.
    Author: Konig W, Bohn A, Bremm KD, Müller P, Szperalski B, Pfeiffer P.
    Journal: Allergol Immunopathol (Madr); 1982; 10(5):385-94. PubMed ID: 6187199.
    Abstract:
    Lipoxygenase factors of arachidonic acid (mono- and di-Hetes) are not only mediators but also modulators of inflammatory reactions. They have chemotactic and spasmogenic properties; the latter are similar to those induced by the slow reacting-substance of anaphylaxis (SRS-A). The eosinophil chemotactic factor has been identified as a lipoxygenase product. Among the chemically mono- and di-Hetes the 5-S-12-R di-Hete (LTB4) and the 5-S 12S di-Hete demonstrated the most pronounced eosinophil chemotactic activity. The phospholipase-arachidonic acid sequence is involved in the IgE induced activation and secretion of human basophils. With arachidonic acid analogs the lipoxygenase transformation pathway is inhibited.
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