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  • Title: Immune response to phosphorylcholine. I. Characterization of the epitope-specific antibody.
    Author: Kluskens L, Lee W, Köhler H.
    Journal: Eur J Immunol; 1976 Jul; 5(7):489-96. PubMed ID: 61872.
    Abstract:
    The antibodies to phosphorylcholine induced in BALB/c mice were isolated and studied with a variety of biochemical and immunochemical methods. Analysis of the idiotype and the hapten-binding specificities showed no differences to the phosphorylcholine-binding myeloma protein TEPC 15, indicating a high degree of homogeneity. However, disc electrophoresis, isoelectric focusing and amino acid composition data indicated large differences in the structure of anti-phosphorylcholine antibody and TEPC 15. By these criteria the anti-phosphorylcholine antibodies from BALB/c mice are of oligoclonal origin.
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