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  • Title: Actions of Ca2+ antagonists on the guinea-pig ileal myenteric plexus preparation.
    Author: Kaplita PV, Triggle DJ.
    Journal: Biochem Pharmacol; 1983 Jan 01; 32(1):65-8. PubMed ID: 6187349.
    Abstract:
    The guinea-pig ileal myenteric plexus preparation has been used to compare the actions of three Ca2+ channel antagonists, D 600 (methoxyverapamil), nicardipine and diltiazem, on smooth muscle contractions and acetylcholine release in response to electrical stimulation. Acetylcholine release was not affected by these agents at concentrations of 10(-6)-10(-5)M. In confirmation of previous work, however, the smooth muscle contractile responses were effectively inhibited at these concentrations. Quercetin, a non-Ca2+ channel antagonist, was approximately equieffective in blocking both acetylcholine release and smooth muscle contractions. These data suggest that differences may exist in the antagonist sensitivity of voltage-dependent Ca2+ channels.
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