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  • Title: Expression of Ia determinants on immunocompetent cells.
    Author: Hammerling GJ, Eichmann K.
    Journal: Eur J Immunol; 1976 Aug; 6(8):565-9. PubMed ID: 61879.
    Abstract:
    The expression of Ia (immune response region-associated) antigens on the surface of lymphocyte subpopulations with defined immunological function has been investigated by negative selection of subpopulations with anti-Ia sera and complement. Ia determinants were found on both unprimed (IgM) and on primed (IgG) antibody-forming precursor cells. No Ia antigens were detected on the surface of helper T cells. In contrast, suppressor T cells were sensitive to treatment with anti-Ia sera and complement demonstrating the presence of Ia determinants on this T cell subpopulation.
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