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  • Title: Microcirculatory flow changes during tissue growth.
    Author: Dudar TE, Jain RK.
    Journal: Microvasc Res; 1983 Jan; 25(1):1-21. PubMed ID: 6188025.
    Abstract:
    Red blood cell (RBC) velocities, lumen diameters, and volumetric flow rates were determined as functions of position and time in the microvessels of repairing tissue grown in a transparent rabbit ear chamber. By making repeated measurements in the same region, and in many instances, in exactly the same vessel over the entire growth period, we have discerned a distinct microcirculatory flow trend. The flow to a particular region (vessel) increases rapidly after an initial lag time, peaks out, and eventually decays to a steady-state level. This behavior is analogous to the vessel density pattern previously observed in this laboratory, but is delayed in time 1 to 2 weeks. These observations are consistent with mechanical, biochemical, and physiological mechanisms underlying neovascularization, tissue growth, and blood flow regulation, and provide a quantitative understanding of these processes.
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