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  • Title: Effect of mirex, dechlorinated mirex derivatives and chlordecone on microsomal mixed-function oxidase activity and other hepatic parameters.
    Author: Chambers JE, Trevathan CA.
    Journal: Toxicol Lett; 1983 Apr; 16(1-2):109-15. PubMed ID: 6188242.
    Abstract:
    The effects of mirex, two monohydrogen and two dihydrogen mirex derivatives, and chlordecone on several hepatic parameters were studied 2 days following a single oral dose of 100 mg/kg in female rats. All compounds increased microsomal cytochrome P-450 content, NADPH-cytochrome c reductase activity, and hepatic ascorbic acid concentration. Microsomal protein concentration was generally increased. All compounds except chlordecone increased relative liver weight and the activities of aminopyrine N-demethylase and p-nitroanisole O-demethylase. Hepatic concentration of protein and glutathione were unaltered. The dechlorinated mirex derivatives caused effects of a magnitude similar to that of mirex, whereas chlordecone was considerably less potent.
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