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  • Title: The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF, from subarachnoid haemorrhage patients, on isolated tissues.
    Author: Tagari PC, Kaye AH, Teddy PJ, Schachter M, Adams CB, Boullin DJ.
    Journal: J Neurol Neurosurg Psychiatry; 1983 Mar; 46(3):214-20. PubMed ID: 6188804.
    Abstract:
    Peri-aneurysmal CSF was obtained at operation from 13 patients with subarachnoid haemorrhage from ruptured intracranial aneurysms. The 5-hydroxytryptamine antagonist ketanserin inhibited contractions of isolated human intracranial arteries, elicited by this CSF. The presence of 5-HT in CSF was confirmed by high performance liquid chromatography. The use of ketanserin in the therapy of postoperative cerebral vasospasm is discussed.
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