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  • Title: High amylase content of neoplastic pleural and pericardial effusion probably secondary to amylase producing tumor cells: report of 2 cases.
    Author: Satz N, Münch R, Kuhlmann U, Pedio G, Gut D, Pei P, Ammann RW.
    Journal: Klin Wochenschr; 1983 Jan 17; 61(2):91-4. PubMed ID: 6188876.
    Abstract:
    We report two cases of malignant pleural and pericardial effusion respectively secondary to bronchogenic carcinomas. In both effusions, a significant elevation of the Salivary-type-amylase fraction was found, while the corresponding values were normal in serum and urine. Electronmicroscopy of the malignant tumor cells from the pleural effusion showed typical electron-dense granules, suggesting zymogen granules. It is concluded that the high amylase content of the effusions was due to secretion of S-type-isoamylase by the tumor cells.
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