These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Demonstration of keratin filaments in thymic nurse cells (TNC) and alloreactivity of TNC-T cell population.
    Author: Vakharia DD.
    Journal: Thymus; 1983; 5(1):43-52. PubMed ID: 6189269.
    Abstract:
    In vitro cultured epithelial reticular cells from foetal thymic explants and thymic nurse cells (TNC) demonstrate the presence of keratin filaments in the cytoplasm. Keratin-positive cells of cultured thymic epithelium are heterogeneous in size and shape as are TNC. T cells inside the nurse cells (TNC-T) ooze out after 18 h of incubation at 37 degrees C. The alloreactivity of these T cells was compared with that of thymocytes and lymph node (LN) cells in a miniaturised mixed lymphocyte reaction using hanging drops set up in Terasaki plates. AKR TNC-T cells and LN cells showed significant proliferative response when stimulated by BALB/c LN cells. No significant proliferative response was shown by non-TNC thymocytes. The data suggest that TNC harbour a mature sample of the T-cell population as judged by alloreactivity.
    [Abstract] [Full Text] [Related] [New Search]