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  • Title: The origin of central pinealopetal nerve fibers in the Mongolian gerbil as demonstrated by the retrograde transport of horseradish peroxidase.
    Author: Møller M, Korf HW.
    Journal: Cell Tissue Res; 1983; 230(2):273-87. PubMed ID: 6189617.
    Abstract:
    The location of perikarya and nerve fibers projecting via the habenular and posterior commissures from the brain into the pineal organ of the Mongolian gerbil was investigated by the use of the retrograde horseradish peroxidase (HRP)-tracing method. After microiontophoretic or hydraulic injection of the tracer into the superficial pineal gland via a glass micropipette, and after survival periods of 6 to 48 h, the animals were transcardially perfused and the brains processed for the histochemical demonstration of the enzyme. In the pineal stalk 15 to 20 nerve fibers, including 4 to 7 myelinated elements, were traced back to the brain. HRP-labeled perikarya were located in the medial and lateral habenular nuclei as well as in the nucleus of the posterior commissure. Few fibers projected rostrally to perikarya in the paraventricular nucleus of the hypothalamus. A striking and persistent finding was the labeling of fibers that, in the habenular area, bent laterad and continued ventral to the optic tract. These fibers originated from perikarya located in the dorsal nucleus of the lateral geniculate body. These results strongly suggest a central innervation of the pineal organ in the Mongolian gerbil originating from hypothalamic and limbic areas of the brain as well as from the optic system.
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