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  • Title: Putative peptide neurotransmitters in human neuropathology: a review of topography and clinical implications.
    Author: Constantinidis J, Bouras C, Richard J.
    Journal: Clin Neuropathol; 1983; 2(2):47-54. PubMed ID: 6189657.
    Abstract:
    In Huntington's disease, there is a decrease of the neuropeptides, substance P, enkephalins, and cholecystokinin in the striatonigral system, whereas in Parkinson's disease an increase of substance P is found in the substantia nigra. Several neuropeptides should be involved in Alzheimer's disease: substance P, endorphins, vasopressin, ACTH, somatostatin, vasoactive intestinal peptide, cholecystokinin, neurotensin, delta sleep-inducing peptide. Alterations of substance P, vasoactive intestinal peptide, cholecystokinin, somatostatin, and endorphins may be related to the pathophysiology of schizophrenia. Delta sleep-inducing peptide may interfere in addiction pathology.
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