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  • Title: Anti-idiotypes against anti-H-2 antibodies VI. Detection of shared idiotypes among monoclonal anti-H-2 antibodies.
    Author: Bluestone JA, Auchincloss H, Sachs DH, Fibi M, Hämmerling GJ.
    Journal: Eur J Immunol; 1983 Jun; 13(6):489-95. PubMed ID: 6190660.
    Abstract:
    Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in conventional alloantisera, detected idiotopes on 3-83 and 100-30 as well as on 2 other monoclonal anti-H-2Kk antibodies. All 4 monoclonal antibodies recognized the same epitope cluster on the Kk molecule and detected the same serological specificity. H-2.5. In contrast, syngeneic and allogeneic anti-idiotype produced against the same monoclonal antibodies did not detect these cross-reactive determinants. In several instances, xenogeneic anti-idiotype reacted with anti-MHC antibodies which recognized distinct H-2 determinants, suggesting that anti-MHC antibodies detecting the same or different specificities may share idiotypic determinants. These reagents may be useful probes of the anti-MHC immune repertoire.
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