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  • Title: Circadian rhythms of RNA, DNA and protein in the rat thyroid, adrenal and testis in chronic pesticide exposure. II. Effects of the herbicides Aminotriazole and Alachlor.
    Author: Nicolau GY.
    Journal: Endocrinologie; 1983; 21(2):105-12. PubMed ID: 6191379.
    Abstract:
    Ninety days of exposure to Aminotriazole (500 ppm/day) leads to changes of the time structure in the rat adrenal and thyroid. The circadian rhythm in adrenal DNA content is not demonstrable in the treated animals as a group phenomenon. There is a phase advance of over five hours (+76 degrees) in the circadian rhythm in adrenal RNA and a phase delay of about nine hours (-136 degrees) in the rhythm in adrenal protein. There is an increase of the mesors (rhythm adjusted mean) and a decrease in the amplitudes of the circadian rhythms in thyroid DNA and RNA content without detectable phase alteraton and a decrease in thyroid protein mesor with a slight but statistically significant phase delay (-25 degrees). The circadian rhythms of the three parameters studied in the testis were not changed by Aminotriazole exposure. Ninety days of exposure to Alachlor (50 ppm/day) had only a minor effect on the testicular rhythms studied. The isolated decrease in thyroid RNA amplitude and the disappearance of the circadian rhythm in adrenal protein content, as a group phenomenon, were the only rhythm alterations found. A chronotoxicological approach may be of importance for the selection to relatively innocuous compounds to be used in agriculture and for the early recognition of undesirable effects in man and animals.
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