These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Naloxone fails to block substance P-induced excitation of spinal nociceptive units.
    Author: Henry JL.
    Journal: Brain Res Bull; 1983 May; 10(5):727-30. PubMed ID: 6191844.
    Abstract:
    In chloralose-anaesthetized cats the iontophoretic application of substance P produced an excitation of dorsal horn nociceptive units, as found in earlier studies. Naloxone (0.1-0.2 mg/kg, IV) failed to abolish this response to substance P in any of the 9 cats studied. In 4 additional cats nociceptive units were tested with morphine (1.0-3.2 mg/kg, IV) and substance P in case the antinociceptive effect of descending pathways is mediated via an excitatory action, but in each case morphine and substance P produced opposite effects (depression and excitation, respectively), suggesting that this was not the case. The present results fail to support a naloxone-antagonizable inhibitory effect of substance P in the spinal cord.
    [Abstract] [Full Text] [Related] [New Search]