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  • Title: Biological activity of canine intestinal cholecystokinin-58.
    Author: Eysselein VE, Deveney CW, Sankaran H, Reeve JR, Walsh JH.
    Journal: Am J Physiol; 1983 Aug; 245(2):G313-20. PubMed ID: 6192728.
    Abstract:
    The biological activity of a recently characterized cholecystokinin molecule, canine CCK-58, has been tested using perifused canine gallbladder strips and isolated mouse pancreatic acini. It has been shown that canine CCK-58, purified by affinity chromatography and molecular sieve chromatography, is biologically as potent as canine CCK-39,33 (component II) and synthetic CCK-8. The biological responses were inhibited by dibutyryl cGMP, a known CCK antagonist. CCK-58 is one of the main large molecular forms of CCK in the intestine mucosa. Whether CCK-58 is only an intracellular precursor of other CCK molecules or an important circulating hormone cannot be determined from the data currently available.
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