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  • Title: Histochemical tumor markers for evaluation of hormone dependence in breast cancer.
    Author: Klein PJ, Vierbuchen M, Schulz KD, Farrar G, Fischer J, Uhlenbruck G, Fischer R.
    Journal: Cancer Detect Prev; 1983; 6(1-2):199-206. PubMed ID: 6192918.
    Abstract:
    Lectin from the peanut (peanut agglutinin = PNA) possesses a high affinity for D-galactosyl-(1-3)-N-acetyl-D-galactosamine, used for histochemical investigations on formalin-fixed tissue sections of normal mammary gland as well as of benign and malignant breast diseases. Thereby, a lectin-binding pattern was found that partly exhibited secretory malfunction. Additional studies with a labeled antibody directed against a milk fat globule membrane glycoprotein, which was isolated by PNA affinity chromatography from human milk, confirmed the PNA receptor as a marker of a milk protein in breast carcinomas. The most important clinicopathological finding, however, was that in accordance with the secretory activity about 77% of PNA-positive tumors responded to endocrine treatment, whereas PNA-negative mammary carcinomas usually failed to show any response to hormonal therapy. These results also correlated with the hormone receptor content of tumor tissue.
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