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  • Title: Salivary secretion induced by substance P.
    Author: Yu JH, Burns SM, Schneyer CA.
    Journal: Proc Soc Exp Biol Med; 1983 Sep; 173(4):467-70. PubMed ID: 6193530.
    Abstract:
    Secretion of fluid, ions, and amylase from parotid and submaxillary glands of rat, induced by intravenous injection of substance P (SP), was examined. The action of SP on salivary glands, like physalaemin, resembled that of cholinergic stimulation. While SP-evoked salivary flow from both glands was blocked by atropine, atropine did not modify composition of SP-evoked saliva. The present study suggests that salivary secretion and secretion of ions and amylase evoked by SP are mediated via SP-sensitive cholinergic receptors and specific SP receptors, respectively.
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