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  • Title: Interaction between heparin and human pregnancy-associated plasma protein A (PAPP-A): a simple purification procedure.
    Author: Davey MW, Teisner B, Sinosich M, Grudzinskas JG.
    Journal: Anal Biochem; 1983 May; 131(1):18-24. PubMed ID: 6193728.
    Abstract:
    Human pregnancy-associated plasma protein A (PAPP-A) binds to heparin-Sepharose. This affinity chromatography preceded by molecular sieve chromatography provides a simple two-step purification procedure of PAPP-A from late pregnancy plasma. One hundred percent of the applied PAPP-A was recovered, with more than 40% being electrophoretically homogeneous after the two procedures. The remaining PAPP-A could be purified by negative affinity chromatography on anti-total human serum immobilized on agarose.
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