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  • Title: The prediction of pregnancy failure by measurement of pregnancy-associated plasma protein A (PAPP-A) following in vitro fertilization and embryo transfer.
    Author: Sinosich MJ, Smith DH, Grudzinskas JG, Saunders DM, Westergaard JG, Teisner B.
    Journal: Fertil Steril; 1983 Oct; 40(4):539-41. PubMed ID: 6194016.
    Abstract:
    Circulating PAPP-A was measured serially in five patients following successful IVF-ET. PAPP-A concentrations were consistently normal in all three patients in whom pregnancies progressed normally to term. Depressed levels of PAPP-A were observed in one patient who miscarried spontaneously at 17 weeks' gestation despite ultrasound evidence of normal fetal development. Circulating PAPP-A was not detected in the fifth patient, whose tubal pregnancy ruptured at 8 weeks. These data are discussed in relation to surveillance of pregnancies following IVF-ET.
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