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  • Title: [Immunoglobulin M and alpha 2-macroglobulin in the amniotic fluid in neural tube defects].
    Author: Briese V, Straube W.
    Journal: Zentralbl Gynakol; 1983; 105(15):977-81. PubMed ID: 6194633.
    Abstract:
    Alpha 1-fetoprotein (AFP), alpha 2-macroglobulin (AMG) and immunoglobulin M (IgM) were estimated quantitatively in 16 amniotic fluid samples of gestational weeks 15 to 21. In 4 pregnancies there were defects of the neural canal (2 anencephalic fetuses, 2 fetuses with meningomyelocele). The other 12 amniotic fluid samples from normal pregnancies are used as control group. AFP, AMG and IgM concentrations were increased in the 4 pathologic samples. AFP was detected using Laurell-technique, AMG and IgM by single radial immunodiffusion.
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