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  • Title: [Correlation between serum IgE level and human basophil degranulation by anti-IgE antibodies].
    Author: Chabane MH, Leynadier F, Lochak C, Nassar A, Dry J.
    Journal: Ann Immunol (Paris); 1983; 134C(3):355-64. PubMed ID: 6194737.
    Abstract:
    The human basophil degranulation test (HBDT) by anti-IgE antibodies was applied in 3 groups of subjects: 20 controls, 26 patients with helminthiasis and 28 allergic patients. Mean degranulation was higher in patients with helminthiasis than in the two other groups. A correlation was found between IgE serum level and HBDT results by anti-IgE (r = 0.373; p less than 0.02) with Spearman's rank correlation test. Therefore, degranulation with anti-IgE antibodies would appear to depend on the quantity of cell-bound IgE rather than on intrinsic basophil sensitivity.
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