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  • Title: [Effect of euphyllin on metabolic processes in blood and tissues during experimental pituitrin hypertension].
    Author: Dunaev VV, Tishkin VS, Samura BA, Dumich VI.
    Journal: Farmakol Toksikol; 1983; 46(5):40-4. PubMed ID: 6195012.
    Abstract:
    A study was made of the effect of euphylline administration (25 mg/kg) for 20 days on some indicators of carbohydrate, energy, lipid and electrolyte metabolism in blood serum and tissues of the heart, aorta and liver during pituitrin hypertension in rabbits experiencing arterial pressure normalization. It was found that euphylline appreciably decreased hypercholesterolemia and hyperlipoproteinemia seen in hypertension. At the same tine the aortal wall showed a decrease in cholesterol content, in lactate dehydrogenase activity, and the normalization of transketolase activity and calcium concentration. In liver tissue, the activity of glycolytic enzymes was inhibited and cholesterol level declined. The heart muscle manifested a decrease in the activity of glycolytic and pentosephosphate pathway enzymes and in that of creatine kinase. The changes in electrolyte balance included sodium elevation in blood serum, heart and liver tissues.
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