These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Altered excitability of afferent C-fibres of the rat distal to a nerve site exposed to capsaicin.
    Author: Welk E, Petsche U, Fleischer E, Handwerker HO.
    Journal: Neurosci Lett; 1983 Aug 08; 38(3):245-50. PubMed ID: 6195557.
    Abstract:
    Excitability of afferent C-fibres in saphenous and coccygeal nerves of rats was studied distal to a nerve site treated with 1% capsaicin for half an hour one day before. This treatment induced the following changes. (a) Fewer C-fibres than in control nerves were excited by natural skin stimulation among those driven by electrical nerve stimulation. Comparison of compound action potentials derived from capsaicin-treated and from untreated contralateral coccygeal nerves indicated that the total number of excitable C-fibres was also diminished. (b) Whereas in a normal rat nerve virtually all unmyelinated nociceptors responding to heat stimulation are also driven by strong mechanical stimuli (MH-nociceptors, polymodal nociceptors), most of them were found to respond only to heat stimulation after local capsaicon treatment of the nerve.
    [Abstract] [Full Text] [Related] [New Search]