These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Clinical performance and endocrine profiles with contraceptive vaginal rings containing a combination of estradiol and d-norgestrel.
    Author: Mishell DR, Moore DE, Roy S, Brenner PF, Page MA.
    Journal: Am J Obstet Gynecol; 1978 Jan 01; 130(1):55-62. PubMed ID: 619648.
    Abstract:
    Contraceptive vaginal rings, impregnated with d-norgestrel (77 mg) and estradiol (29-66 mg) were studied in 10 subjects aged 24-28. 5 subjects were studied for 3 cycles and 5 for 6 cycles. The rings were inserted (on Day 5) for 3 weeks and removed for 1 week to allow withdrawal bleeding. Serum samples were obtained at least 3 times/week; estradiol and d-norgestrel were assayed in each sample, and progesterone weekly. Clinical acceptance was good. Ovulation was inhibited in all treatment cycles and resumed within 1 month following completion of the trial. There was regular withdrawal bleeding, no episodes of failure of withdrawal bleeding, and only 3 days of breakthrough spotting. Serum d-norgestrel levels were relatively constant in each subject except for the 1st half of the 1st treatment cycle which had slightly higher levels. Serum estradiol levels rose rapidly following insertion of the ring to levels between 100-300 pg/ml, but then declined over the next few days to levels generally less than 50 pg/ml. After treatment, mean levels of the binding capacity of corticosteroid-binding-globulin did not become significantly elevated and serum triglycerides declined. This method has the advantage of inhibition of ovulation and good control of bleeding without the disadvantage of producing some adverse metabolic effects.
    [Abstract] [Full Text] [Related] [New Search]