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  • Title: Cystic fibrosis serum stimulates mucin secretion but not calcium efflux from rat submandibular acini.
    Author: McPherson MA, Dodge JA, Goodchild MC.
    Journal: Clin Chim Acta; 1983 Dec 15; 135(2):181-8. PubMed ID: 6197214.
    Abstract:
    Cystic fibrosis serum stimulated release of mucins from rat submandibular acini to a significantly greater degree than did control serum. This action was not due to non-specific cell lysis, as monitored by lactate dehydrogenase release and was not accompanied by increases in 45Ca2+-efflux. The actions of cystic fibrosis serum and control serum in stimulating amylase release from rat exocrine pancreatic acini could not be distinguished. Thus, a specific action of cystic fibrosis serum in increasing mucin secretion, but not calcium permeability, in rat exocrine acini has been demonstrated.
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